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Innate and adaptive immunity

Lookup NU author(s): Dr Louise MichaelisORCiD


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The innate and adaptive immune systems are often described as contrasting separate arms of the host response; however, they usually act together, with the innate response representing the first line of host defense and the adaptive response becoming prominent after several days as antigen-specific T and B cells have undergone clonal expansion. Components of the innate system contribute to activation of the antigen-specific cells. Additionally, the antigen-specific cells amplify their responses by recruiting innate effector mechanisms to bring about the complete control of invading microbes. Thus, although the innate and adaptive immune responses are fundamentally different in their mechanisms of action, synergy between them is essential for an intact, fully effective immune response. © 2013 Woodhead Publishing Limited. All rights reserved.

Publication metadata

Author(s): Noakes PS, Michaelis LJ

Publication type: Book Chapter

Publication status: Published

Book Title: Diet, Immunity and Inflammation

Year: 2013

Pages: 3-33

Print publication date: 01/09/2013

Online publication date: 27/03/2014

Series Title: Woodhead Publishing Series in Food Science, Technology and Nutrition

Publisher: Woodhead Publishing Limited

Place Published: Cambridge


DOI: 10.1533/9780857095749.1.3

Library holdings: Search Newcastle University Library for this item

ISBN: 9780857090379