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Modern immunosuppression

Lookup NU author(s): Rodrigo Figueiredo, Dr Colin Wilson


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Organ transplantation provides both life-saving and life-enhancing function for patients suffering from end-stage organ failure. Transplantation has only been possible due to the advances in immunosuppression. The viability of a transplanted organ depends on modulation of the human immune system to avoid rejection in response to foreign antigens. Modern immunosuppression consists of multi-modal therapy (chemical drugs and biological agents) acting on different parts of the immune response. Three phases of immunosuppression can be recognized: induction, maintenance and withdrawal. All patients must continue to take at least some immunosuppression to prevent rejection. Developments in immunosuppressant regimens have dramatically improved transplant success rates and experience over the years has helped to understand the side-effects and long-term complications of immunosuppression. Research continues to identify both novel compounds and ways of optimizing the use of current drugs. © 2014 Elsevier Ltd. All rights reserved.

Publication metadata

Author(s): Figueiredo RS, Wilson C

Publication type: Review

Publication status: Published

Journal: Surgery

Year: 2014

Volume: 32

Issue: 7

Pages: 344-350

Print publication date: 01/07/2014

Online publication date: 14/06/2014

Acceptance date: 01/01/1900

ISSN (print): 0263-9319

ISSN (electronic): 1878-1764

Publisher: Elsevier Ltd


DOI: 10.1016/j.mpsur.2014.04.014