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Two- and three-dimensional tissue culture methods for hard tissue engineering

Lookup NU author(s): Dr Mark Birch, Dr Kathleen Wright


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A complex array of cellular and molecular events underlies the (patho)physiology of bone and cartilage. Tissue culture approaches have provided great insight into the mechanisms that regulate the activity of bone cells (osteoclasts, osteoblasts, osteocytes) and cartilage cells (chondrocytes). These approaches include assays that have evolved to investigate the differentiation processes of progenitor cells as well as characterising the functionality of mature cells. What has become increasingly apparent is that the three-dimensional environment is an important regulator in the control of cell activity, and tissue culture approaches have been developed to evaluate the role of these substrate-derived cues. © 2013 Woodhead Publishing Limited. All rights reserved.

Publication metadata

Author(s): Birch MA, Wright KE

Publication type: Book Chapter

Publication status: Published

Book Title: Standardisation in Cell and Tissue Engineering: Methods and Protocols

Year: 2013

Pages: 54-76

Online publication date: 27/03/2014

Publisher: Elsevier Ltd.


DOI: 10.1533/9780857098726.1.54

Library holdings: Search Newcastle University Library for this item

ISBN: 9780857094193