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Ras/Raf/MEK/ERK pathway activation in childhood acute lymphoblastic leukemia and its therapeutic targeting

Lookup NU author(s): Dr Thomas Knight, Professor Julie Irving



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutically exploited and may guide new therapies needed for relapsed acute lymphoblastic leukemia and other high risk subgroups © 2014 Knight and Irving.

Publication metadata

Author(s): Knight T, Irving JAE

Publication type: Review

Publication status: Published

Journal: Frontiers in Oncology

Year: 2014

Volume: 4

Online publication date: 24/06/2014

Acceptance date: 06/06/2014

ISSN (electronic): 2234-943X

Publisher: Frontiers Research Foundation


DOI: 10.3389/fonc.2014.00160