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Lookup NU author(s): Dr Thomas Knight,
Professor Julie Irving
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutically exploited and may guide new therapies needed for relapsed acute lymphoblastic leukemia and other high risk subgroups © 2014 Knight and Irving.
Author(s): Knight T, Irving JAE
Publication type: Review
Publication status: Published
Journal: Frontiers in Oncology
Online publication date: 24/06/2014
Acceptance date: 06/06/2014
ISSN (electronic): 2234-943X
Publisher: Frontiers Research Foundation