Browse by author
Lookup NU author(s): Dr Gajanan Sherbet
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
© 2014 Published by Elsevier Ireland Ltd. HER2 positive breast cancers have been shown to have a greater propensity to metastasise to the brain. This may be due to several reasons, including the creation of a "sanctuary-site" for tumour in the brain following trastuzumab therapy. Elucidating the mechanism of this phenomenon may aid the prevention or intervention and treatment of such metastases, but research is limited by the deficiency and diminished access of CNS tissue. However, CNS penetrable HER2 receptor antagonists such as lapatinib and intrathecal administration of trastuzumab might benefit patients, and are worthy of further investigation. New avenues of molecular approach have focused on manipulating signal transduction system involved in HER2 function. The importance of systemic therapies and those targeted to metastatic lesions is emphasised and evaluated here.
Author(s): Patil A, Sherbet GV
Publication type: Note
Publication status: Published
Journal: Cancer Letters
Print publication date: 28/03/2015
Online publication date: 18/12/2014
Acceptance date: 11/12/2014
ISSN (print): 0304-3835
ISSN (electronic): 1872-7980
Publisher: Elsevier Ireland Ltd
PubMed id: 25529010