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Intercontinental dispersal of HIV-1 subtype B associated with transmission among men who have sex with men in Japan

Lookup NU author(s): Dr Matthias Schmid, Dr Brendan PayneORCiD

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Abstract

© 2014, American Society for Microbiology. All Rights Reserved. Transmission clusters of HIV-1 subtype B uniquely associated with the epidemic among men who have sex with men (MSM) in East Asia have recently been identified. Using the Los Alamos HIV sequence database and the UK HIV drug resistance database, we explored possible links between HIV MSM epidemics in East Asia and the rest of the world by using phylogenetic and molecular clock analyses. We found that JP.MSM.B-1, a subtype B MSM variant that accounts for approximately one-third of the infections among Japanese MSM, was detected worldwide, in the United Kingdom (n=13), mainland China (n=3), the United States, Germany, Canada, and Taiwan (n=1 each). Interestingly, 10 United Kingdom samples plus two from Germany and the United States formed a distinct monophyletic subgroup within JP.MSM.B-1. The estimated divergence times of JP.MSM.B-1 and the latter subgroup were ~1989 and ~1999, respectively. These dates suggest that JP.MSM.B-1 was circulating for many years in Japan among MSM before disseminating to other countries, most likely through global MSM networks. A significant number of other Asian MSM HIV lineages were also detected in the UK HIV drug resistance database. Our study provides insight into the regional and global dispersal of Asian MSM HIV lineages. Further study of these strains is warranted to elucidate viral migration and the interrelationship of HIV epidemics on a global scale.

Publication metadata

Author(s): Takebe Y, Naito Y, Raghwani J, Fearnhill E, Sano T, Kusagawa S, Mbisa JL, Zhang H, Matano T, Brown AJL, Pybus OG, Dunn D, Kondo M, Aitken C, Asboe D, Pozniak A, Cane P, Castro H, Dolling D, Porter K, Tostevin A, Chadwick D, Churchill D, Clark D, Collins S, Delpech V, Douthwaite S, Geretti AM, Hale A, Hue S, Kaye S, Kellam P, Lazarus L, Mbisa T, Mackie N, Orkin C, Pillay D, Phillips A, Sabin C, Smit E, Templeton K, Tilston P, Webster D, Williams I, Zuckerman M, Greatorex J, O'Shea S, Mullen J, Cox A, Tandy R, Fawcett T, Hopkins M, Ashton L, Booth C, Garcia-Diaz A, Shepherd J, Schmid ML, Payne B, Pereira S, Hubb J, Kirk S, MacLean A, Gunson R, Coughlin K, Fradette L, White E

Publication type: Article

Publication status: Published

Journal: Journal of Virology

Year: 2014

Volume: 88

Issue: 17

Pages: 9864-9876

Print publication date: 01/09/2014

Online publication date: 18/06/2014

Acceptance date: 09/06/2014

ISSN (print): 0022-538X

ISSN (electronic): 1098-5514

Publisher: American Society for Microbiology

URL: https://doi.org/10.1128/JVI.01354-14

DOI: 10.1128/JVI.01354-14

PubMed id: 24942575

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