Osteogenic sarcoma. A study of six hundred cases

Gerrand, CH; Rankin, K

doi:10.1007/978-1-4471-5451-8_121

Osteogenic sarcoma. A study of six hundred cases

Lookup NU author(s): Craig Gerrand, Dr Kenneth Rankin ORCiD

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Abstract

© 2014 Springer-Verlag London. All rights are reserved. Background This is a retrospective study of 600 patients with pathologically verifi ed osteogenic sarcoma (excluding tumours of the jaws and parosteal osteogenic sarcoma). Methodology Four hundred and eight were traced for 5-year follow-up of whom eighty-three (20.3 %) survived more than 5 years. Results The survival rate (17.1 %) for patients whose tumours were predominantly osteoblastic was lower, but not to a statistically signifi cant degree, than the rate for those with chondroblastic or fi broblastic tumours. Over 25 % of those with tumours in the more readily treatable sites, namely distal to the proximal end of the humerus or femur, survived 5 years. The more anaplastic sarcomata were associated with a poorer prognosis than the average, but the difference was not statistically signifi cant. Two patients survived long intervals after resection for pulmonary metastasis. Twenty patients had osteogenic sarcoma that developed in lesions of Paget's disease with three surviving for long periods. Sixteen had osteogenic sarcoma that arose in bones that had been irradiated previously all with survival of less than 3 years. Conclusions It is concluded that vigorous, prompt treatment should be employed for osteogenic sarcoma, which may result in a gratifying number of survivors obtained.