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Diagnosis and treatment of chronic myeloid leukemia

Lookup NU author(s): Professor Stephen O'Brien


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© 2013 Springer Science+Business Media New York. All rights reserved. The original recognition of leukemia in the nineteenth century and the story of our progressive understanding of the biology and the development of treatment of chronic myeloid leukemia (CML) have been well reviewed in recent years [1, 2]. Today the diagnosis of CML usually presents few problems. In contrast, planning a therapeutic strategy for a patient who presents in chronic phase and monitoring a patient who starts treatment with a tyrosine kinase inhibitor (TKI) present a number of challenges. The same is true for a patient in chronic phase whose disease proves resistant to initial treatment with a TKI. Even more difficult may be the issue of how best to treat a patient presenting in or progressing to an advanced phase of CML. In this chapter, we will review some of the essentials of diagnosis of CML, which will be mostly self-evident to practicing hematologists, but the main focus will be on available treatment options, the results to date of using these various options, and guidance on therapeutic strategy.

Publication metadata

Author(s): O'Brien SG, Goldman JM

Editor(s): Peter H. Wiernik, John M. Goldman, Janice P. Dutcher, Robert A. Kyle

Publication type: Book Chapter

Publication status: Published

Book Title: Neoplastic Diseases of the Blood

Year: 2013

Pages: 45-62

Online publication date: 27/07/2012

Publisher: Springer

Place Published: New York


DOI: 10.1007/978-1-4614-3764-2_5

Library holdings: Search Newcastle University Library for this item

ISBN: 9781461437635