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Type II toxin-antitoxins loci: The relBE family

Lookup NU author(s): Professor Kenn Gerdes


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© 2013 Springer-Verlag Berlin Heidelberg. All rights reserved. RelBE of Escherichia coli K-12 is a paradigm TA locus. Here, I describe the discovery of relBE and review the genetic, physiological, biochemical and structural analyses that have led to important insights into TA biology. Five relBE homologues of K-12 are also described while the 6th (mqsRA) is treated in a separate Chapter. Finally, a discussion of the possible biological functions of relBE and other type II TA loci sets the stage for future work on prokaryotic type II TA loci.

Publication metadata

Author(s): Gerdes K

Publication type: Book Chapter

Publication status: Published

Book Title: Prokaryotic Toxin-Antitoxins

Year: 2013

Pages: 69-92

Print publication date: 01/11/2013

Online publication date: 19/10/2012

Publisher: Springer-Verlag Berlin Heidelberg


DOI: 10.1007/978-3-642-33253-1_5

Library holdings: Search Newcastle University Library for this item

ISBN: 9783642332531