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RIPOSTE: a framework for improving the design and analysis of laboratory-based research

Lookup NU author(s): Dr Amy AndersonORCiD, Dr Carmen Martin-RuizORCiD, Professor Dawn Teare


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© 2015, eLife Sciences Publications Ltd. All rights reserved. Lack of reproducibility is an ongoing problem in some areas of the biomedical sciences. Poor experimental design and a failure to engage with experienced statisticians at key stages in the design and analysis of experiments are two factors that contribute to this problem. The RIPOSTE (Reducing IrreProducibility in labOratory STudiEs) framework has been developed to support early and regular discussions between scientists and statisticians in order to improve the design, conduct and analysis of laboratory studies and, therefore, reduce irreproducibility. This framework is intended for use during the early stages of a research project, when specific questions or hypotheses are proposed. The essential points within the framework are explained and illustrated using three examples (a medical equipment test, a macrophage study and a gene expression study). Sound study design minimises the possibility of bias being introduced into experiments and leads to higher quality research with more reproducible results.

Publication metadata

Author(s): Masca NGD, Hensor EMA, Cornelius VR, Buffa FM, Marriott HM, Eales JM, Messenger MP, Anderson AE, Boot C, Bunce C, Goldin RD, Harris J, Hinchliffe RF, Junaid H, Kingston S, Martin-Ruiz C, Nelson CP, Peacock J, Seed PT, Shinkins B, Staples KJ, Toombs J, Wright AKA, Dawn Teare M

Publication type: Article

Publication status: Published

Journal: eLife

Year: 2015

Volume: 4

Issue: MAY

Pages: 1-45

Online publication date: 07/05/2015

Acceptance date: 01/01/1900

ISSN (electronic): 2050-084X

Publisher: eLife Sciences Publications Ltd


DOI: 10.7554/eLife.05519


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