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Social variables predict gains in cognitive scores across the preschool years in children with birth weights 500 to 1250 grams

Lookup NU author(s): Professor Sunil Sinha, Dr Win Tin, Unni Wariyar OBE, Professor Nicholas EmbletonORCiD, Dr Ravi Swamy, Dr C Harikumar

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Abstract

Copyright © 2015 Elsevier Inc. All rights reserved. Objective To determine the extent that social variables influence cognitive development of very low birth weight (VLBW) infants across the preschool years. Study design Participants were VLBW (500-1250 g) children enrolled in the Caffeine for Apnea of Prematurity randomized trial between 1999 and 2004. We investigated the relationships between 4 potential social advantages: higher maternal education, higher paternal education, caregiver employment, and 2 biologic parents in the same home'and gain in cognitive scores. Cognitive assessments were performed at the corrected ages of 18 months (Mental Development Index score on the Bayley Scales of Infant Development II) and 5 years (Full Scale IQ on the Wechsler Preschool and Primary Scale of Intelligence III). Cognitive gain was computed by subtracting each individual 18-month Mental Development Index score from the corresponding Full Scale IQ at 5 years. Results Data were available for 1347 children. Mean (SD) cognitive scores were 90.8 (15.7) at 18 months and 98.9 (14.5) at 5 years. Multivariable regression showed that higher maternal education, higher paternal education, and caregiver employment had independent and additive effects of similar size on cognitive gain (P < .001); the mean cognitive gain between 18 months and 5 years increased by 3.6 points in the presence of each of these advantages. When all 3 were present, cognitive scores improved on average by 10.9 points compared with children without any of these advantages. Conclusion In VLBW children, a count of 3 social advantages strongly predicts gains in cognitive scores across the preschool years.

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Author(s): Manley BJ, Roberts RS, Doyle LW, Schmidt B, Anderson PJ, Barrington KJ, Bohm B, Golan A, Van Wassenaer-Leemhuis AG, Davis PG, D'Ilario J, Cairnie J, Dix J, Adams BA, Warriner E, Kim M-HM, Argus B, Callanan C, Duff J, McDonald M, Asztalos E, Hohn D, Lacy M, Haslam R, Barnett C, Goodchild L, Lontis RM, Fraser S, Keng J, Saunders K, Opie G, Kelly E, Woods H, Marchant E, Turner A-M, Davis N, Magrath E, Williamson A, Bairam A, Belanger S, Fraser A, Blayney M, Lemyre B, Frank J, Solimano A, Synnes A, Grunau RE, Hubber-Richard P, Rogers M, Mackay M, Petrie-Thomas J, Butt A, Van Wassenaer A, Nuytemans D, Houtzager B, Van Sonderen L, Regev R, Itzchack N, Arnon S, Chalaf A, Ohlsson A, O'Brien K, Hamilton A-M, Chan ML, Sankaran K, Proctor P, Goldsch-Lerman E, Reynolds G, Dromgool B, Meskell S, Parr V, Maher C, Broom M, Kecskes Z, Ringland C, McMillan D, Spellen E, Sauve RS, Christianson H, Anseeuw-Deeks D, Creighton D, Heath J, Alvaro R, Chiu A, Porter C, Turner G, Moddemann D, Granke N, Penner K, Bow J, Mulder A, Wassenberg R, Van Der Hoeven M, Clarke M, Parfitt J, Parker K, Nwaesei C, Ryan H, Saunders C, Schulze A, Wermuth I, Hilgendorff A, Flemmer AW, Herlenius E, Legnevall L, Lagercrantz H, Matthew D, Amos W, Tulsiani S, Tan-Dy C, Turner M, Phelan C, Shinwell ES, Levine M, Juster-Reicher A, Khairy M, Grier P, Vachon J, Perepolkin L, Sinha SK, Tin W, Fritz S, Walti H, Royer D, Halliday H, Millar D, Mayes C, McCusker C, McLaughlin O, Fahnenstich H, Tillmann B, Weber P, Wariyar U, Embleton N, Swamy R, Bucher HU, Fauchere J-C, Dietz V, Harikumar C, Asztalos EV, Dewey D, Gent M, Fraser W, Hey E, Perlman M, Thorpe K, Gray S, Chambers C, Costantini L, Yacura W, McGean E, Scapinello L

Publication type: Article

Publication status: Published

Journal: Journal of Pediatrics

Year: 2015

Volume: 166

Issue: 4

Pages: 870-876

Print publication date: 01/04/2015

Online publication date: 29/01/2015

Acceptance date: 08/12/2014

ISSN (print): 0022-3476

ISSN (electronic): 1097-6833

Publisher: Mosby Inc.

URL: https://doi.org/10.1016/j.jpeds.2014.12.016

DOI: 10.1016/j.jpeds.2014.12.016

PubMed id: 25641237

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