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Harmonized benchmark labels of the hippocampus on magnetic resonance: The EADC-ADNI project

Lookup NU author(s): Dr Michael FirbankORCiD


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© 2015 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved. Background: A globally harmonized protocol (HarP) for manual hippocampal segmentation based on magnetic resonance has been recently developed by a task force from European Alzheimer's Disease Consortium (EADC) and Alzheimer's Disease Neuroimaging Initiative (ADNI). Our aim was to produce benchmark labels based on the HarP for manual segmentation. Methods: Five experts of manual hippocampal segmentation underwent specific training on the HarP and segmented 40 right and left hippocampi from 10 ADNI subjects on both 1.5 Tand 3 T scans. An independent expert visually checked segmentations for compliance with the HarP. Descriptive measures of agreement between tracers were intraclass correlation coefficients (ICCs) of crude volumes and similarity coefficients of three-dimensional volumes. Results: Two hundred labels have been provided for the 20 magnetic resonance images. Intra- And interrater ICCs were .0.94, and mean similarity coefficients were 1.5 T, 0.73 (95% confidence interval [CI], 0.71-0.75); 3 T, 0.75 (95% CI, 0.74-0.76). Conclusion: Certified benchmark labels have been produced based on the HarP to be used for tracers' training and qualification.

Publication metadata

Author(s): Bocchetta M, Boccardi M, Ganzola R, Apostolova LG, Preboske G, Wolf D, Ferrari C, Pasqualetti P, Robitaille N, Duchesne S, Jack CR, Frisoni GB, Bartzokis G, Decarli C, Detoledo-Morrell L, Fellgiebel A, Firbank M, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pruessner JC, Soininen H, Wang L

Publication type: Article

Publication status: Published

Journal: Alzheimer's and Dementia

Year: 2015

Volume: 11

Issue: 2

Pages: 151-160.e5

Print publication date: 01/02/2015

Online publication date: 13/10/2014

Acceptance date: 01/01/1900

ISSN (print): 1552-5260

ISSN (electronic): 1552-5279

Publisher: Elsevier Inc.


DOI: 10.1016/j.jalz.2013.12.019

PubMed id: 25223727


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