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Local drug delivery in the management of periodontal diseases Part 2: Specific agents

Lookup NU author(s): Jane Eastham, Emeritus Professor Robin Seymour


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Local drug delivery systems (LDDs) are mainly used as adjuncts to root surface instrumentation (RSI) in the management of periodontal disease. A range of antibacterial agents have been used for this purpose and include the tetracyclines, chlorhexidine, metronidazole, azithromycin, clarithromycin and moxifloxacin. More recently, other non-antibacterial agents have been incorporated into local delivery devices and include simvastatin, metformin and alendronate. This paper will review the effectiveness of such agents when used as an adjunct to conventional non-surgical periodontal therapy.

Publication metadata

Author(s): Eastham JE, Seymour RA

Publication type: Article

Publication status: Published

Journal: Dental Update

Year: 2014

Volume: 41

Issue: 9

Pages: 796-810

Print publication date: 01/11/2014

Acceptance date: 01/01/1900

ISSN (print): 0305-5000

Publisher: George Warman Publications