Toggle Main Menu Toggle Search

Open Access padlockePrints

Endometrial injury prior to assisted reproductive techniques for recurrent implantation failure: A systematic literature review

Lookup NU author(s): Dr Nikoletta Panagiotopoulou, Dr Stamatios Karavolos, Dr Meenakshi Choudhary


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2015 Elsevier Ireland Ltd. All rights reserved. All rights reserved.Endometrial injury to improve implantation for women undergoing assisted reproductive techniques has attracted a lot of attention recently and has rapidly become incorporated into clinical practice. The aim of this study is, thus, to assess the effectiveness and safety of endometrial injury performed in the cycle preceding assisted reproductive techniques in women with recurrent implantation failure. Electronic database searches, including MEDLINE, EMBASE, CENTRAL and grey literature, up to 30th May 2015 were conducted with no restrictions. Randomized controlled trials comparing endometrial injury versus placebo or no treatment in the cycle preceding assisted reproductive techniques in women with recurrent implantation failure were selected. The primary outcome was live birth rate. Secondary outcomes were clinical pregnancy, implantation, miscarriage and procedure-related complication rates. Of the 1115 publications identified, 4 met the inclusion criteria. Meta-analysis was not possible due to significant clinical heterogeneity among the included studies. Patients' characteristics differed, as did the intervention used with endometrial injury being performed at different phases of the preceding menstrual cycle. Moreover, the effect of endometrial injury on live birth and clinical pregnancy rates were inconsistent among the included studies. In summary, there is currently insufficient evidence to support the use of endometrial injury in women with recurrent implantation failure undergoing assisted reproductive techniques while the procedure-associated complication rate has not been assessed. Clinical implementation should, thus, be deferred until robust evidence becomes available.

Publication metadata

Author(s): Panagiotopoulou N, Karavolos S, Choudhary M

Publication type: Review

Publication status: Published

Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology

Year: 2015

Volume: 193

Pages: 27-33

Print publication date: 01/10/2015

Online publication date: 17/07/2015

Acceptance date: 30/06/2015

ISSN (print): 0301-2115

ISSN (electronic): 1872-7654

Publisher: Elsevier Ireland Ltd


DOI: 10.1016/j.ejogrb.2015.06.026

PubMed id: 26218557