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Semantic profiles in mild cognitive impairment associated with Alzheimer’s and Parkinson’s diseases

Lookup NU author(s): Professor David Burn


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© 2015, CIC Edizioni Internazionali s.r.l. All rights reserved. The temporal and the prefrontal cortices have different roles in semantic information processing: the temporal lobe is where knowledge is stored (Graham and Hodges, 1997), whereas the prefrontal cortex is more specifically involved in executive aspects of semantic processing. Relatively little is known about the semantic profiles of mild cognitive impairment (MCI) in Alzheimer’s disease (AD) and Parkinson’s disease (PD). This observational study investigated naming and semantic questionnaire performances in three groups of subjects: 10 patients with the amnestic-type MCI prodrome of AD (aMCI), 10 patients with early-stage executive-type MCI in PD (MCI-PD), and 10 normal subjects. The MCI-PD subjects demonstrated inferior performances on a semantic questionnaire, whereas the aMCI group displayed modest difficulties in a naming task. These differences may be explained by topographical differences in pathological involvement. Since the frontal areas are more functionally impaired in PD, we hypothesize that the semantic deficit may be a consequence of a deficiency in control of semantic processing. On the other hand, the semantic deficit in aMCI may be related to a lexical-semantic storage dysfunction resulting from pathological involvement of the temporal lobe.

Publication metadata

Author(s): Guidi M, Paciaroni L, Paolini S, Scarpino O, Burn DJ

Publication type: Article

Publication status: Published

Journal: Functional Neurology

Year: 2015

Volume: 30

Issue: 2

Pages: 113-118

Print publication date: 01/04/2015

Acceptance date: 01/01/1900

ISSN (print): 0393-5264

ISSN (electronic): 1971-3274

Publisher: CIC Edizioni Internazionali s.r.l.


DOI: 10.11138/FNeur/2015.30.2.113


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