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Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria

Lookup NU author(s): Dr John Perry

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Abstract

© 2015 Elsevier Ltd. New fluorogenic enzyme substrates were synthesized by the coupling of aminonaphthalenesulfonamides or 6-hydrazinobenz[de]isoquinoline-1,3-diones with β-alanine. The 6-hydrazinobenz[de]isoquinoline-1,3-diones were also condensed with a range of aryl aldehydes to give the corresponding hydrazones. The photophysical properties of the synthesized amines and hydrazines and their amide, hydrazide and hydrazone derivatives, were examined and they were also incorporated into Columbia agar in order to determine their potential for the detection of pathogenic bacteria.

Publication metadata

Author(s): Luo JL, Jin T, Varadi L, Perry JD, Hibbs DE, Groundwater PW

Publication type: Article

Publication status: Published

Journal: Dyes and Pigments

Year: 2016

Volume: 125

Pages: 15-26

Print publication date: 01/02/2016

Online publication date: 08/10/2015

Acceptance date: 22/09/2015

ISSN (print): 0143-7208

ISSN (electronic): 1873-3743

Publisher: Elsevier Ltd

URL: http://doi.org/10.1016/j.dyepig.2015.09.031

DOI: 10.1016/j.dyepig.2015.09.031

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