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Small cell neuroendocrine carcinoma of larynx: Case series and literature review

Lookup NU author(s): Professor Vinidh Paleri, Dr Charles Kelly


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© 2015 JLO (1984) Limited. Primary small cell neuroendocrine carcinoma of larynx is a rare, aggressive type of malignancy. As only about 200 cases worldwide have been reported, any larger institutional experience is valuable. This study reports our experience in managing this rare entity. Methods: Of the nine patients identified, three had metastatic cancer at the time of diagnosis. Four patients underwent radical treatment: one was managed surgically followed by adjuvant chemotherapy and consolidation radiotherapy; the remaining three were treated with neoadjuvant chemotherapy and definitive radiotherapy. Results: Of the 4 patients treated with radical intent, 1 was alive and disease free after 99 months, 2 died of metastatic disease after 22 and 26 months, and 1 was alive after 20 months with a diagnosis of recurrent disease. Conclusion: Our relatively small number of patients confirms other centres' experiences. This cancer has a poorer prognosis than most other head and neck cancers. Although the logistics would be challenging, there is a need for international multicentre trials for this disease modelled on those performed for other cancers, as has been done for paediatric malignancies.

Publication metadata

Author(s): Iqbal MS, Paleri V, Moor J, Dobrowsky W, Kelly C, Kovarik J

Publication type: Article

Publication status: Published

Journal: Journal of Laryngology and Otology

Year: 2015

Volume: 129

Issue: 9

Pages: 910-915

Print publication date: 01/09/2015

Online publication date: 15/07/2015

Acceptance date: 13/01/2015

ISSN (print): 0022-2151

ISSN (electronic): 1748-5460

Publisher: Cambridge University Press


DOI: 10.1017/S0022215115001668

PubMed id: 26173932


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