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Minlon™: New, Long Read, Portable Nucleic Acid Sequencing Device

Lookup NU author(s): Emeritus Professor Alan Ward

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Abstract

© 2015, Chonnam National University Medical School. All rights Reserved. The MinION™ is a miniature nanopore-based analysis device in which the characteristics of an analyte, as it passes through the nanopore, cause changes in the flow of ions through the pore, which are measured, as current flow, by a low noise amplifier and analogue-to-digital converter. Potentially any molecular analyte capable of passing through the nanopore may modify the flow of ions and generate a signal which might be diagnostic. In practice the current device is focussed on DNA sequencing, directly sequencing RNA is a likely development. With the MinION Access Program making the MinIONTM widely available a flood of applications exploiting its real time, long read capabilities have been published. We review the background to the technology and compare it to current next generation sequencing.

Publication metadata

Author(s): Ward AC, Kim W

Publication type: Review

Publication status: Published

Journal: Journal of Bacteriology and Virology

Year: 2015

Volume: 45

Issue: 4

Pages: 285-303

Print publication date: 24/12/2015

Online publication date: 24/12/2015

Acceptance date: 08/10/2015

ISSN (print): 1598-2467

ISSN (electronic): 2093-0429

Publisher: Chonnam National University Medical School

URL: http://dx.doi.org/10.4167/jbv.2015.45.4.285

DOI: 10.4167/jbv.2015.45.4.285

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