Summary, discussion, and conclusions

Balali-Mood, M; Abdollahi, M

doi:10.1007/978-1-4471-5625-3_9

Summary, discussion, and conclusions

Lookup NU author(s): Professor Mahdi Balali-Mood

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.

Abstract

© Springer-Verlag London 2014. Toxicology of organophosphorus (OP) compounds is important to scientists and health professionals because of their widespread use and serious concerns of toxicity. A discussion of all basic and clinical aspects of OP compounds from their synthesis and toxicity, to novel biomarkers, epidemiology of poisoning, occupational and environmental exposure, risk assessment, clinical management and guidance on prevention and control have been covered in this book. Chemistry and classifications of OP compounds from first synthesis to the present, physical and chemical properties, chemical reactions and mechanism of actions have been also described. History of use and epidemiology of OPs poisonings including all the applications as the pesticide or possibly as the chemical warfare nerve agents have been defined. Since toxicity of OPs can occur through acute or chronic exposures and there are differences in the approach to diagnose and treatment of exposed, all the effects, mechanisms and relative toxicity of OPs have been described thoroughly. For instance, the mechanisms related to delayed neurotoxicity, teratogenicity, mutagenicity and carcinogenicity of OPs have been presented. Mechanisms of OP's toxicity in various organs have been described in a way to help discovery of novel biomarkers. Since clinical management of OPs poisoning is somehow different regarding its use as the pesticide or possibly the chemical warfare nerve agent, information about types of effects as, management, complications, and follow up of the patients have been provided. Occupational and environmental aspects of OPs are also important and thus occupational poisonings and environmental toxicities have been described and also the role of world organization for prohibition of chemical weapons (OPCW) has been addressed.