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The Mononuclear Phagocyte System in Organ Transplantation

Lookup NU author(s): Professor Matthew CollinORCiD


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© Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons. The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells (DCs). Over the past few decades, classification of the cells of the MPS has generated considerable controversy. Recent studies into the origin, developmental requirements and function of MPS cells are beginning to solve this problem in an objective manner. Using high-resolution genetic analyses and fate-mapping studies, three main mononuclear phagocyte lineages have been defined, namely, macrophage populations established during embryogenesis, monocyte-derived cells that develop during adult life and DCs. These subsets and their diverse subsets have specialized functions that are largely conserved between species, justifying the introduction of a new, universal scheme of nomenclature and providing the framework for therapeutic manipulation of immune responses in the clinic. In this review, we have commented on the implications of this novel MPS classification in solid organ transplantation.

Publication metadata

Author(s): Ochando J, Kwan W-H, Ginhoux F, Hutchinson JA, Hashimoto D, Collin M

Publication type: Review

Publication status: Published

Journal: American Journal of Transplantation

Year: 2016

Volume: 16

Issue: 4

Pages: 1053-1069

Print publication date: 01/04/2016

Online publication date: 28/01/2016

Acceptance date: 08/11/2015

ISSN (print): 1600-6135

ISSN (electronic): 1600-6143

Publisher: Blackwell Publishing Ltd


DOI: 10.1111/ajt.13627