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Lookup NU author(s): Professor Matthew CollinORCiD
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© Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons. The mononuclear phagocyte system (MPS) comprises monocytes, macrophages and dendritic cells (DCs). Over the past few decades, classification of the cells of the MPS has generated considerable controversy. Recent studies into the origin, developmental requirements and function of MPS cells are beginning to solve this problem in an objective manner. Using high-resolution genetic analyses and fate-mapping studies, three main mononuclear phagocyte lineages have been defined, namely, macrophage populations established during embryogenesis, monocyte-derived cells that develop during adult life and DCs. These subsets and their diverse subsets have specialized functions that are largely conserved between species, justifying the introduction of a new, universal scheme of nomenclature and providing the framework for therapeutic manipulation of immune responses in the clinic. In this review, we have commented on the implications of this novel MPS classification in solid organ transplantation.
Author(s): Ochando J, Kwan W-H, Ginhoux F, Hutchinson JA, Hashimoto D, Collin M
Publication type: Review
Publication status: Published
Journal: American Journal of Transplantation
Print publication date: 01/04/2016
Online publication date: 28/01/2016
Acceptance date: 08/11/2015
ISSN (print): 1600-6135
ISSN (electronic): 1600-6143
Publisher: Blackwell Publishing Ltd