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Lookup NU author(s): Professor Jeffrey Pearson,
Dr Peter Chater,
Dr Matthew WilcoxORCiD
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© 2016 Future Science Ltd. The key criterion for a nanoparticle drug-delivery system is the ability to produce substantial bioavailability without damaging the physiological protective mechanisms. The main area for drug delivery is the aerodigestive tract. All epithelial surfaces have a membrane-bound layer and in the lung this layer is surmounted by a gel layer. In the gastrointestinal tract the membrane-bound mucin layer is covered by a mucus bilayer. The pore sizes of mucus gels are around 100 to 200 nm. Consequently, only nanoparticles in this size range could potentially penetrate without modification of these layers. To study nanoparticle permeation with results that pertain to in vivo conditions, native mucus mucin preparations must be used. Strategies to increase pores in mucus gels are discussed herein.
Author(s): Pearson JP, Chater PI, Wilcox MD
Publication type: Review
Publication status: Published
Journal: Therapeutic Delivery
Online publication date: 01/04/2016
Acceptance date: 01/01/1900
ISSN (print): 2041-5990
ISSN (electronic): 2041-6008
Publisher: Future Science Ltd