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Chronic pancreatitis

Lookup NU author(s): Jeremy French, Richard Charnley


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© 2016 Published by Elsevier Ltd. Chronic pancreatitis is distinguished by structural and functional criteria. Alcohol is the major aetiological factor, but about 20% of patients have another cause such as hereditary pancreatitis. Abdominal pain is the usual presenting feature, often as recurrent attacks of acute pancreatitis but chronic pancreatitis may be clinically silent. The pathogenesis of chronic pancreatitis is incompletely understood. Diagnosis is usually made on imaging (CT, magnetic resonance cholangiopancreatography, endoscopic ultrasound). Complications include exocrine and endocrine insufficiency, obstructive jaundice, duodenal obstruction, left-sided portal hypertension, and the development of pancreatic cancer. Overall management is difficult and depends upon symptoms, morphological characteristics and complications. Treatment options include medical, endoscopic, and surgical strategies; the latter is reserved for patients with complications. Early involvement of a specialist centre in the care of patients with complicated chronic pancreatitis is important and should be encouraged.

Publication metadata

Author(s): French JJ, Charnley RM

Publication type: Article

Publication status: Published

Journal: Surgery (Oxford)

Year: 2016

Volume: 34

Issue: 6

Pages: 301-306

Print publication date: 01/06/2016

Online publication date: 29/04/2016

Acceptance date: 02/04/2016

ISSN (print): 0263-9319

ISSN (electronic): 1878-1764

Publisher: Elsevier Ltd


DOI: 10.1016/j.mpsur.2016.03.009


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