Toggle Main Menu Toggle Search

Open Access padlockePrints

Clinical outcomes of amniotic membrane transplantation in the management of acute ocular chemical injury

Lookup NU author(s): Professor Francisco FigueiredoORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Background Amniotic membrane transplantation (AMT) has been used in the management of acute ocular chemical burns to promote epithelialisation, reduce inflammation and restore ocular surface integrity. The aim of this study is to analyse the morphological and functional outcomes of patients receiving AMT after ocular chemical burn. Methods We performed a retrospective analysis of all patients treated for acute ocular chemical burn between 1998 and 2008 in two participating centres (University of Duisburg-Essen, Germany and Royal Victoria Infirmary, Department of Ophthalmology, Newcastle University, UK). Ocular chemical burns were classified by Roper-Hall and Dua classifications. Results 72 eyes of 54 consecutive patients aged 37.3â €...years (±SD 11.6â €...years) were included in this cohort study. 7 chemical burns were acid burns, 61 were alkaline and 4 were of unknown origin. In 37 eyes (51.4%), AMT was applied within the first 6â €...days after injury. Mean follow-up time was 36.4â €...months (median 18.5; 1.3-117.3 â €...months). Overall, 29 eyes (40.3%) achieved a best-corrected visual acuity of LogMAR 0.2 (0.63 decimal) or better at final visit. Complete 360° limbal stem cell deficiency (LSCD) occurred in 33 eyes (45.8%), while partial LSCD occurred in 21 eyes (29.2%). Conclusion AMT is an effective adjunctive treatment in the management of acute ocular chemical burns to support epithelial healing and restore ocular surface integrity with potential to improve vision. However, long-term debilitated vision remained in those with severe burns complicated by LSCD.

Publication metadata

Author(s): Westekemper H, Figueiredo FC, Siah WF, Wagner N, Steuhl K-P, Meller D

Publication type: Article

Publication status: Published

Journal: British Journal of Ophthalmology

Year: 2017

Volume: 101

Issue: 2

Pages: 103-107

Print publication date: 01/02/2017

Online publication date: 20/01/2017

Acceptance date: 27/03/2016

ISSN (print): 0007-1161

ISSN (electronic): 1468-2079

Publisher: BMJ Publishing Group


DOI: 10.1136/bjophthalmol-2015-308037


Altmetrics provided by Altmetric