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Lookup NU author(s): Professor Francisco Figueiredo
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Background Amniotic membrane transplantation (AMT) has been used in the management of acute ocular chemical burns to promote epithelialisation, reduce inflammation and restore ocular surface integrity. The aim of this study is to analyse the morphological and functional outcomes of patients receiving AMT after ocular chemical burn. Methods We performed a retrospective analysis of all patients treated for acute ocular chemical burn between 1998 and 2008 in two participating centres (University of Duisburg-Essen, Germany and Royal Victoria Infirmary, Department of Ophthalmology, Newcastle University, UK). Ocular chemical burns were classified by Roper-Hall and Dua classifications. Results 72 eyes of 54 consecutive patients aged 37.3â €...years (±SD 11.6â €...years) were included in this cohort study. 7 chemical burns were acid burns, 61 were alkaline and 4 were of unknown origin. In 37 eyes (51.4%), AMT was applied within the first 6â €...days after injury. Mean follow-up time was 36.4â €...months (median 18.5; 1.3-117.3 â €...months). Overall, 29 eyes (40.3%) achieved a best-corrected visual acuity of LogMAR 0.2 (0.63 decimal) or better at final visit. Complete 360° limbal stem cell deficiency (LSCD) occurred in 33 eyes (45.8%), while partial LSCD occurred in 21 eyes (29.2%). Conclusion AMT is an effective adjunctive treatment in the management of acute ocular chemical burns to support epithelial healing and restore ocular surface integrity with potential to improve vision. However, long-term debilitated vision remained in those with severe burns complicated by LSCD.
Author(s): Westekemper H, Figueiredo FC, Siah WF, Wagner N, Steuhl K-P, Meller D
Publication type: Article
Publication status: Published
Journal: British Journal of Ophthalmology
Print publication date: 01/02/2017
Online publication date: 20/01/2017
Acceptance date: 27/03/2016
ISSN (print): 0007-1161
ISSN (electronic): 1468-2079
Publisher: BMJ Publishing Group
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