Toggle Main Menu Toggle Search

Open Access padlockePrints

Molecular pathways and animal models of truncus arteriosus

Lookup NU author(s): Amy-Leigh Johnson, Dr Simon BamforthORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© Springer-Verlag Wien 2016. In normal cardiovascular development in birds and mammals, the outflow tract of the heart is divided into two distinct channels to separate the oxygenated systemic blood flow from the deoxygenated pulmonary circulation. When the process of outflow tract septation fails, a single common outflow vessel persists resulting in a serious clinical condition known as persistent truncus arteriosus or common arterial trunk. In this chapter we will review molecular pathways and the cells that are known to play a role in the formation and development of the outflow tract and the genetic manipulation of these models that can result in common arterial trunk.

Publication metadata

Author(s): Johnson A-L, Bamforth SD

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways

Year: 2015

Pages: 569-578

Print publication date: 18/12/2015

Acceptance date: 01/01/1900

Publisher: Springer-Verlag Wien


DOI: 10.1007/978-3-7091-1883-2_48

Library holdings: Search Newcastle University Library for this item

ISBN: 9783709118832