Molecular pathways and animal models of truncus arteriosus

Johnson, A-L; Bamforth, SD

doi:10.1007/978-3-7091-1883-2_48

Molecular pathways and animal models of truncus arteriosus

Lookup NU author(s): Amy-Leigh Johnson, Dr Simon Bamforth ORCiD

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Abstract

© Springer-Verlag Wien 2016. In normal cardiovascular development in birds and mammals, the outflow tract of the heart is divided into two distinct channels to separate the oxygenated systemic blood flow from the deoxygenated pulmonary circulation. When the process of outflow tract septation fails, a single common outflow vessel persists resulting in a serious clinical condition known as persistent truncus arteriosus or common arterial trunk. In this chapter we will review molecular pathways and the cells that are known to play a role in the formation and development of the outflow tract and the genetic manipulation of these models that can result in common arterial trunk.