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Lookup NU author(s): Amy-Leigh Johnson,
Dr Simon BamforthORCiD
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© Springer-Verlag Wien 2016. The great arteries of the vertebrate carry blood from the heart to the systemic circulation and are derived from the pharyngeal arch arteries. In higher vertebrates, the pharyngeal arch arteries are a symmetrical series of blood vessels that rapidly remodel during development to become the asymmetric aortic arch arteries carrying oxygenated blood from the left ventricle via the outflow tract. At the base of the aorta, as well as the pulmonary trunk, are the arterial, or semilunar, valves. These valves each have three leaflets and prevent the backflow of blood into the heart. During development, the process of aortic arch and valve formation may go wrong, resulting in cardiovascular defects, and these may, at least in part, be caused by genetic mutations. In this chapter, we will review models harbouring genetic mutations that result in cardiovascular defects affecting the great arteries and the arterial valves.
Author(s): Johnson A-L, Bamforth SD
Publication type: Book Chapter
Publication status: Published
Book Title: Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways
Print publication date: 18/12/2015
Acceptance date: 01/01/1900
Publisher: Springer-Verlag Wien
Library holdings: Search Newcastle University Library for this item