Toggle Main Menu Toggle Search

Open Access padlockePrints

Molecular pathways and animal models of semilunar valve and aortic arch anomalies

Lookup NU author(s): Amy-Leigh Johnson, Dr Simon BamforthORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© Springer-Verlag Wien 2016. The great arteries of the vertebrate carry blood from the heart to the systemic circulation and are derived from the pharyngeal arch arteries. In higher vertebrates, the pharyngeal arch arteries are a symmetrical series of blood vessels that rapidly remodel during development to become the asymmetric aortic arch arteries carrying oxygenated blood from the left ventricle via the outflow tract. At the base of the aorta, as well as the pulmonary trunk, are the arterial, or semilunar, valves. These valves each have three leaflets and prevent the backflow of blood into the heart. During development, the process of aortic arch and valve formation may go wrong, resulting in cardiovascular defects, and these may, at least in part, be caused by genetic mutations. In this chapter, we will review models harbouring genetic mutations that result in cardiovascular defects affecting the great arteries and the arterial valves.

Publication metadata

Author(s): Johnson A-L, Bamforth SD

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways

Year: 2015

Pages: 513-526

Print publication date: 18/12/2015

Acceptance date: 01/01/1900

Publisher: Springer-Verlag Wien


DOI: 10.1007/978-3-7091-1883-2_42

Library holdings: Search Newcastle University Library for this item

ISBN: 9783709118832