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Molecular pathways and animal models of d-transposition of the great arteries

Lookup NU author(s): Amy-Leigh Johnson, Dr Simon BamforthORCiD


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© Springer-Verlag Wien 2016. During normal cardiovascular development, the outflow tract becomes septated and rotates so that the separate aorta and pulmonary trunk are correctly aligned with the left and right ventricles, respectively. However, when this process goes wrong, the aorta and pulmonary trunk are incorrectly positioned resulting in oxygenated blood being directly returned to the lungs, with deoxygenated blood being delivered to the systemic circulation. This is termed transposition of the great arteries (TGA). The precise etiology of TGA is not known, but the use of animal models has elucidated that genes involved in left–right determination of the embryonic body play key roles. Other factors such as retinoic acid levels are also crucial. This chapter reviews the animal models that can be manipulated genetically or with exogenous agents to present with TGA.

Publication metadata

Author(s): Johnson A-L, Bamforth SD

Publication type: Book Chapter

Publication status: Published

Book Title: Congenital Heart Diseases: The Broken Heart: Clinical Features, Human Genetics and Molecular Pathways

Year: 2015

Pages: 449-458

Print publication date: 06/01/2016

Acceptance date: 01/01/1900

Publisher: Springer-Verlag Wien


DOI: 10.1007/978-3-7091-1883-2_36

Library holdings: Search Newcastle University Library for this item

ISBN: 9783709118832