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The life and works of S100P - from conception to can

Lookup NU author(s): Dr YuZhu Cheng


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Since its discovery in 1992, the small, 10.4 kDa calcium-binding protein S100P has gained the attention of researchers from different scientific fields due to its potential roles in both healthy and neoplastic tissues. Although not ubiquitously expressed, in tissues where it is present, S100P is associated with distinct changes in cellular behaviour. In this review we have summarized the evolutionary history of S100P, its expression and involvement in implantation and human embryonic development, as well as important functions in normal tissue and cancer. Finally, we have demonstrated its pivotal role as a potential diagnostic and therapeutic target, which opens promising avenues for further fruitful research on S100P.

Publication metadata

Author(s): Prica F, Radon T, Cheng Y, Crnogorac-Jurcevic T

Publication type: Review

Publication status: Published

Journal: American Journal of Cancer Research

Year: 2016

Volume: 6

Issue: 2

Pages: 562-576

Print publication date: 01/02/2016

Online publication date: 15/01/2016

Acceptance date: 10/01/2016

ISSN (print): 2156-6976

Publisher: E-Century Publishing Corporation