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Collagen scaffolds for corneal regeneration

Lookup NU author(s): Dr Ricardo Martins GouveiaORCiD, Professor Che ConnonORCiD


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© 2016, 2010 Elsevier Ltd. All rights reserved. The present chapter sets out to define the usefulness of collagen in corneal tissue engineering. Briefly outlining collagen's role in the normal cornea and its biochemistry, the chapter goes on to describe recent approaches to fabricating collagen-based corneal constructs taking in both top-down and bottom-up rational design, as well as synthetic alternatives to collagen. Particular attention is paid to both decellularization and recellularization techniques, as well as the resulting changes in the collagen gel's ultrastructural, biophysical, and biochemical properties.

Publication metadata

Author(s): Gouveia RM, Connon CJ

Publication type: Book Chapter

Publication status: Published

Book Title: Biomaterials and Regenerative Medicine in Ophthalmology: Second Edition

Year: 2016

Pages: 151-177

Print publication date: 20/04/2016

Online publication date: 29/04/2016

Acceptance date: 01/01/2016

Series Title: Woodhead Publishing Series in Biomaterials

Publisher: Elsevier Inc.

Place Published: Cambridge


DOI: 10.1016/B978-0-08-100147-9.00007-9

Notes: Hardback ISBN 9780081001479

Library holdings: Search Newcastle University Library for this item

ISBN: 9780081001844