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An overview of the genetics, mechanisms and management of NAFLD and ALD

Lookup NU author(s): Professor Quentin AnsteeORCiD


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© Royal College of Physicians 2015. All rights reserved.Alcoholic liver disease (ALD) and, increasingly, non-alcoholic fatty liver disease (NAFLD) are common causes of advanced liver disease in many developed countries including the UK. Both diseases share parallel natural histories, progressing from steatosis, to steatohepatitis and fibrosis/cirrhosis; and are characterised by substantial interindividual variation in disease outcome. This article will provide an overview of disease mechanisms, genetic modifiers and management, focusing principally on NAFLD, while drawing parallels between the two conditions where appropriate.

Publication metadata

Author(s): Rowell RJ, Anstee QM

Publication type: Review

Publication status: Published

Journal: Clinical Medicine, Journal of the Royal College of Physicians of London

Year: 2015

Volume: 15

Issue: 6

Pages: s77-s82

Print publication date: 01/12/2015

Acceptance date: 01/01/1900

ISSN (print): 1470-2118

ISSN (electronic): 1473-4893

Publisher: Royal College of Physicians


DOI: 10.7861/clinmedicine.15-6-s77