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Detection of L-alanylaminopeptidase activity in microorganisms using fluorogenic self-immolative enzyme substrates

Lookup NU author(s): Dr John Perry

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Abstract

© 2016 Elsevier Ltd A series of fluorogenic enzymatic substrates that incorporate a self-immolative spacer were synthesised for the purpose of identifying L-alanylaminopeptidase activity in microorganisms in agar media. These substrates resulted in the generation of fluorescent microorganism colonies with Gram-negative microorganisms.

Publication metadata

Author(s): Cellier M, James AL, Lowe J, Orenga S, Perry JD, Rasul AK, Stanforth SP

Publication type: Article

Publication status: Published

Journal: Bioorganic and Medicinal Chemistry

Year: 2016

Volume: 24

Issue: 18

Pages: 4066-4074

Print publication date: 15/09/2016

Online publication date: 27/06/2016

Acceptance date: 25/06/2016

ISSN (print): 0968-0896

ISSN (electronic): 1464-3391

Publisher: Elsevier Ltd

URL: https://doi.org/10.1016/j.bmc.2016.06.051

DOI: 10.1016/j.bmc.2016.06.051

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