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Is protection in HIV infection due to Bw4 or not to Bw4?

Lookup NU author(s): Dr Tevfik Dorak


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First Paragraph: Polymorphism in HLA class I genes influences the natural history of HIV infection. Studies have shown that homozygosity at any of the classic HLA class I loci is distinctly disadvantageous. In addition, certain specific class I alleles have been convincingly associated with either favourable (B*27 and B*57) or unfavourable (B*35) consequences in populations that differ by ethnicity, HIV-1 clade, and dominant route of transmission. Last paragraph: Whether Bw4 itself—or certain of the alleles that display it—selectively confer protection against HIV disease will likely be resolved by inquiry along two lines. Population studies can confirm or refute the observed association. Meanwhile, the search for insight into viral pathogenesis will continue with intense effort by immunologists to elucidate class I HLA-restricted CTL response as a cornerstone of adaptive immunity and to explore the interaction of NK receptors with HLA class I-encoded ligands as a critical mechanism of innate immunity. Together those efforts should clarify the role of Bw4 in the context of the overall influence of class I polymorphism on the pathogenesis of HIV/AIDS and other viral diseases.

Publication metadata

Author(s): Dorak MT; Kaslow RA; Tang JJ

Publication type: Article

Publication status: Published

Journal: Lancet Infectious Diseases

Year: 2001

Volume: 1

Issue: 4

Pages: 221-222

ISSN (print): 1473-3099

ISSN (electronic): 1474-4457

Publisher: The Lancet Publishing Group


DOI: 10.1016/S1473-3099(01)00116-5

PubMed id: 11871508


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