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Lookup NU author(s): Dr Lucy Walker, Paul Baker, Dr Richard Holleyman, Professor David Deehan
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© 2016 European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) Purpose: The use of antibiotic-loaded bone cement (ALBC) has a range of indications for use in orthopaedics. It has the advantage of delivering high loads of antibiotics to a targeted site, thereby avoiding the side effects associated with systemic administration. However, there is concern that the use of ALBC may precipitate the development of antibiotic-resistant bacteria. Methods: This review focuses on (1) the published research using both animal and human models examining the association between ALBC and the induction of microbial resistance (2) the mechanisms by which antimicrobial resistance develop (3) the research pertaining to specific classes of antibiotics commonly used in orthopaedic practice (4) the recent developments in calcium sulphate beads, nanoparticles and chitosan, as alternative antimicrobial treatments for periprosthetic joint infections. Conclusion: The literature for and against a link between ALBC and the development of microbiological resistance is reviewed and presented. It is concluded that further research is needed to develop a defined set of indications for the use of ALBC in the management of periprosthetic joint infection. In addition, further research into alternative antimicrobial therapies in this area should be encouraged.
Author(s): Walker LC, Baker P, Holleyman R, Deehan D
Publication type: Article
Publication status: Published
Journal: Knee Surgery, Sports Traumatology, Arthroscopy
Year: 2017
Volume: 25
Issue: 12
Pages: 3808-3817
Print publication date: 01/12/2017
Online publication date: 12/09/2016
Acceptance date: 31/08/2016
ISSN (print): 0942-2056
ISSN (electronic): 1433-7347
Publisher: Springer Verlag
URL: https://doi.org/10.1007/s00167-016-4309-5
DOI: 10.1007/s00167-016-4309-5
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