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The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial

Lookup NU author(s): Professor Fraser Birrell


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© 2016 Osteoarthritis Research Society International Objective Epidemiological data suggest low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee osteoarthritis (OA). This study aimed to assess whether vitamin D supplementation can slow the rate of progression. Method A 3-year, double-blind, randomised, placebo-controlled trial of 474 patients aged over 50 with radiographically evident knee OA comparing 800 IU cholecalciferol daily with placebo. Primary outcome was difference in rate of medial joint space narrowing (JSN). Secondary outcomes included lateral JSN, Kellgren & Lawrence grade, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, stiffness and the Get up and Go test. Results Vitamin D supplementation increased 25-OH-D3 from an average of 20.7 (standard deviation (SD) 8.9) μg/L to 30.4 (SD 7.7) μg/L, compared to 20.7 (SD 8.1) μg/L and 20.3 (SD 8.1) μg/L in the placebo group. There was no significant difference in the rate of JSN over 3 years in the medial compartment of the index knee between the treatment group (average −0.01 mm/year) and placebo group (−0.08 mm/year), average difference 0.08 mm/year (95% confidence interval (CI) [−0.14–0.29], P = 0.49). No significant interaction was found between baseline vitamin D levels and treatment effect. There were no significant differences for any of the secondary outcome measures. Conclusion Vitamin D supplementation did not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a 3-year period. On the basis of these findings we consider that vitamin D supplementation has no role in the management of knee OA.

Publication metadata

Author(s): Arden NK, Cro S, Sheard S, Dore CJ, Bara A, Tebbs SA, Hunter DJ, James S, Cooper C, O'Neill TW, Macgregor A, Birrell F, Keen R

Publication type: Article

Publication status: Published

Journal: Osteoarthritis and Cartilage

Year: 2016

Volume: 24

Issue: 11

Pages: 1858-1866

Print publication date: 01/11/2016

Online publication date: 02/06/2016

Acceptance date: 23/05/2016

ISSN (print): 1063-4584

ISSN (electronic): 1522-9653

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.joca.2016.05.020


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