Toggle Main Menu Toggle Search

Open Access padlockePrints

Calorie restriction and reversal of type 2 diabetes

Lookup NU author(s): Professor Roy Taylor


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2016 Informa UK Limited, trading as Taylor & Francis Group. Introduction: Type 2 diabetes causes major global health problems and has been believed to be a lifelong condition with inevitable worsening. Steadily increasing numbers of drugs appeared to be required to achieve even modest control. Early type 2 diabetes has now been shown to be reversed by substantial weight loss and this has allowed temporal tracking of the underlying pathophysiological changes. Areas covered: In early type 2 diabetes, negative calorie balance decreases liver fat within days, and allows return of normal control of hepatic glucose production. Over 8 weeks, the negative calorie balance allows the raised levels of intra-pancreatic fat and simultaneously first phase insulin secretion to normalise. These findings are consistent with the 2008 Twin Cycle Hypothesis of the etiology and pathogenesis of type 2 diabetes. Individuals develop type 2 diabetes when they exceed their personal fat threshold for safe storage of fat and there is no difference in pathophysiology between those with BMI above or below 30 kg/m2. Expert commentary: Type 2 diabetes can now be understood as a state of excess fat in liver and pancreas, and remains reversible for at least 10 years in most individuals.

Publication metadata

Author(s): Taylor R

Publication type: Review

Publication status: Published

Journal: Expert Review of Endocrinology and Metabolism

Year: 2016

Volume: 11

Issue: 6

Pages: 521-528

Online publication date: 30/09/2016

Acceptance date: 19/09/2016

ISSN (print): 1744-6651

ISSN (electronic): 1744-8417

Publisher: Taylor and Francis Ltd


DOI: 10.1080/17446651.2016.1239525