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Factors associated with current and severe physical side-effects after prostate cancer treatment: What men report

Lookup NU author(s): Professor Linda Sharp


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© 2016 John Wiley & Sons Ltd. We identified patient and disease characteristics associated with (1) "current" physical side-effects of any severity; and (2) "severe" physical side-effects "ever" experienced by 3,348 (54%) prostate cancer (PCa) survivors in Ireland diagnosed 2-18 years previously. Postal questionnaires collected symptoms at diagnosis, post-biopsy complications, comorbidities, primary treatments and physical side-effects post-treatment (urinary incontinence, erectile dysfunction, libido loss, bowel problems, breast changes, hot flushes, and fatigue, "ever" and "current" at time of questionnaire completion). Men were grouped by "early" (localised) and "late" (locally advanced/advanced) disease at diagnosis. Multivariable logistic regression analysis identified patient and disease-related factors associated with post-treatment side-effects. Complications post-biopsy were associated with higher risk of "current" libido loss and impotence. Radical prostatectomy was associated with higher risk of "current" and "severe" incontinence, libido loss and impotence in both early and late disease. In early disease, brachytherapy was associated with lower risk of "current" fatigue and "severe" impotence. Comorbidities were associated with higher risk of "current" experience of four side-effects (incontinence, libido loss, bowel problems, fatigue). Men on active surveillance/watchful-waiting reported lower risk of sexual dysfunction. These findings could inform development of tailored information on side-effects, which, in turn, could inform treatment decision-making and post-treatment monitoring.

Publication metadata

Author(s): Steentjes L, Siesling S, Drummond FJ, van Manen JG, Sharp L, Gavin A

Publication type: Article

Publication status: Published

Journal: European Journal of Cancer Care

Year: 2018

Volume: 27

Issue: 1

Print publication date: 01/01/2018

Online publication date: 10/10/2016

Acceptance date: 26/08/2016

ISSN (print): 0961-5423

ISSN (electronic): 1365-2354

Publisher: John Wiley & Sons Ltd


DOI: 10.1111/ecc.12589


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