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Lookup NU author(s): Dr Girish Viswanathan
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© 2016 International Federation for Medical and Biological Engineering The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress was observed for 90% AS as compared to other models that could result in the rupture of coronary artery. The FFR of 90% AS is found to be considerably low.
Author(s): Kamangar S, Badruddin IA, Govindaraju K, Nik-Ghazali N, Badarudin A, Viswanathan GN, Ahmed NJS, Khan TMY
Publication type: Article
Publication status: Published
Journal: Medical and Biological Engineering and Computing
Year: 2017
Volume: 55
Issue: 8
Pages: 1451-1461
Print publication date: 01/08/2017
Online publication date: 21/12/2016
Acceptance date: 01/12/2016
ISSN (print): 0140-0118
ISSN (electronic): 1741-0444
Publisher: Springer Verlag
URL: https://doi.org/10.1007/s11517-016-1604-8
DOI: 10.1007/s11517-016-1604-8
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