Toggle Main Menu Toggle Search

Open Access padlockePrints

Neonatal listeriosis in the UK 2004–2014

Lookup NU author(s): Professor Nicholas EmbletonORCiD, Dr Ruppa Geethanath, Dr Mithilesh Lal


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


© 2016 The British Infection Association Objective To define the clinical features and outcomes of neonatal listeriosis, and identify the maternal risk factors to seek scope for improvement. Methods Neonatal listeriosis was identified prospectively from a United Kingdom neonatal infection surveillance network (neonIN) between 2004 and 2014. The participating neonatal units completed a study-specific proforma. Results The incidence of neonatal listeriosis was 3.4 per 100,000 live births. Of the 21 cases identified, 19 were confirmed with a median gestational age of 33 weeks and a median birth weight of 1960 g. The majority had clinical features (95%, 18/19), presented within the first 24 h (95%, 18/19), and received penicillin empirically (94%, 18/19). The neonatal case-fatality rate was 21% (24% if probable cases were included). A proportion of mothers were investigated (60%, 12/18) and diagnosed with listeriosis (58%, 7/12); 32% (6/19) were treated with antibiotics but only 33% (6/12) included penicillin. Discussion Despite its rarity and the prompt and appropriate use of antibiotics neonatal listeriosis has a high case-fatality rate. There is room for improvement in the adherence to the empiric antibiotic choice for puerperal sepsis, according to the national guidelines as this, would target listeriosis. Strategies should be in place to prevent pregnancy-associated listeriosis in higher risk population.

Publication metadata

Author(s): Sapuan S, Kortsalioudaki C, Anthony M, Chang J, Embleton ND, Geethanath RM, Gray J, Greenough A, Lal MK, Luck S, Pattnayak S, Reynolds P, Russell AB, Scorrer T, Turner M, Heath PT, Vergnano S

Publication type: Article

Publication status: Published

Journal: Journal of Infection

Year: 2017

Volume: 74

Issue: 3

Pages: 236-242

Print publication date: 01/03/2017

Online publication date: 17/11/2016

Acceptance date: 10/11/2016

ISSN (print): 0163-4453

ISSN (electronic): 1532-2742

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.jinf.2016.11.007


Altmetrics provided by Altmetric