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Conserved Sequence Processing in Primate Frontal Cortex

Lookup NU author(s): Dr Ben Wilson, Professor Christopher Petkov



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2016 Elsevier Ltd An important aspect of animal perception and cognition is learning to recognize relationships between environmental events that predict others in time, a form of relational knowledge that can be assessed using sequence-learning paradigms. Humans are exquisitely sensitive to sequencing relationships, and their combinatorial capacities, most saliently in the domain of language, are unparalleled. Recent comparative research in human and nonhuman primates has obtained behavioral and neuroimaging evidence for evolutionarily conserved substrates involved in sequence processing. The findings carry implications for the origins of domain-general capacities underlying core language functions in humans. Here, we synthesize this research into a ‘ventrodorsal gradient’ model, where frontal cortex engagement along this axis depends on sequencing complexity, mapping onto the sequencing capacities of different species.

Publication metadata

Author(s): Wilson B, Marslen-Wilson WD, Petkov CI

Publication type: Review

Publication status: Published

Journal: Trends in Neurosciences

Year: 2017

Volume: 40

Issue: 2

Pages: 72-82

Print publication date: 01/02/2017

Online publication date: 05/01/2017

Acceptance date: 02/04/2016

ISSN (print): 0166-2236

ISSN (electronic): 1878-108X

Publisher: Elsevier Ltd


DOI: 10.1016/j.tins.2016.11.004