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Real world outcomes of ocriplasmin use by members of the British and Eire Association of Vitreoretinal Surgeons

Lookup NU author(s): Professor David SteelORCiD



This is the authors' accepted manuscript of an article that has been published in its final definitive form by Nature Publishing Group, 2017.

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© 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved 0950-222X/17.PurposeTo describe a survey of the use of ocriplasmin by members of the British and Eire Association of VitreoRetinal Surgeons (BEAVRS) for VitreoMacular Traction (VMT) and Full Thickness Macular Hole (FTMH) and compare it to published MIVI TRUST trial data.MethodsAll 173 BEAVRS members were contacted by email in October 2014 requesting data on all cases treated with ocriplasmin up to that date. The total number of cases, FTMH closure rate, VMT release rate and the frequency of adverse events were recorded. Results were compared with trial data.Results48 members responded reporting results from 241 eyes. The respective BEAVRS and MIVI TRUST trial closure rates for small FTMHs were 42.1 and 58.3% (P=0.09) and for medium FTMH 12.7 and 36.7% (P=0.01). The respective VMT release rates were 34.1 and 37.4% (P=NS). Retinal detachment was observed in 3.3% of the BEAVRS cohort compared with 0.4% in MIVI TRUST. Reduction in visual acuity to <6/60 was observed in 5.8% of the BEAVRS cohort and 0.6% in MIVI TRUST. Other complications not reported in the MIVI TRUST trial included an increase in FTMH basal diameter following unsuccessful ocriplasmin use in 46.9% of BEAVRS cases and zonular instability at the time of subsequent phacoemulsification in 2.4%.ConclusionMacular hole closure rates were lower in the BEAVRS survey than published in the MIVI TRUST trial data. The incidence of adverse events was greater than previously reported. The reasons for these disparities are unknown but could include positive reporting bias inherent to retrospective surveys, treatment and population differences.

Publication metadata

Author(s): Haynes RJ, Yorston D, Laidlaw DAH, Keller J, Steel DHW

Publication type: Article

Publication status: Published

Journal: Eye

Year: 2017

Volume: 31

Issue: 1

Pages: 107-112

Print publication date: 01/01/2017

Online publication date: 02/09/2016

Acceptance date: 11/07/2016

Date deposited: 11/09/2017

ISSN (print): 0950-222X

ISSN (electronic): 1476-5454

Publisher: Nature Publishing Group


DOI: 10.1038/eye.2016.195


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