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STROKOG (stroke and cognition consortium): An international consortium to examine the epidemiology, diagnosis, and treatment of neurocognitive disorders in relation to cerebrovascular disease

Lookup NU author(s): Professor Raj KalariaORCiD, Dr Louise Allan, Sebastian Kohler

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Abstract

© 2016 The Authors Introduction The Stroke and Cognition consortium (STROKOG) aims to facilitate a better understanding of the determinants of vascular contributions to cognitive disorders and help improve the diagnosis and treatment of vascular cognitive disorders (VCD). Methods Longitudinal studies with ≥75 participants who had suffered or were at risk of stroke or TIA and which evaluated cognitive function were invited to join STROKOG. The consortium will facilitate projects investigating rates and patterns of cognitive decline, risk factors for VCD, and biomarkers of vascular dementia. Results Currently, STROKOG includes 25 (21 published) studies, with 12,092 participants from five continents. The duration of follow-up ranges from 3 months to 21 years. Discussion Although data harmonization will be a key challenge, STROKOG is in a unique position to reuse and combine international cohort data and fully explore patient level characteristics and outcomes. STROKOG could potentially transform our understanding of VCD and have a worldwide impact on promoting better vascular cognitive outcomes.

Publication metadata

Author(s): Sachdev PS, Lo JW, Crawford JD, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gele P, Deplanque D, Bae H-J, Lim J-S, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong Y-H, Tan HH, Chen C, Xin X, Kalaria RN, Allan LM, Akinyemi RO, Ogunniyi A, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee B-C, Yu K-H, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Lipnicki DM, Kochan NA, Sachdev PS, Lo JW, Crawford JD, Lipnicki DM, Kochan NA, Mellon L, Hickey A, Williams D, Bordet R, Mendyk A-M, Gele P, Deplanque D, Bae H-J, Lim J-S, Brodtmann A, Werden E, Cumming T, Kohler S, Verhey FRJ, Dong Y-H, Xu J, Chen C, Kalaria RN, Allan LM, Akinyemi R, Ogunniyi A, Kalariai RN, Klimkowicz-Mrowiec A, Dichgans M, Wollenweber FA, Zietemann V, Hoffmann M, Desmond DW, Linden T, Blomstrand C, Fagerberg B, Skoog I, Godefroy O, Barbay M, Roussel M, Lee B-C, Yu K-H, Lim J-S, Wardlaw J, Makin SJ, Doubal FN, Chappell FM, Srikanth VK, Thrift AG, Donnan GA, Kandiah N, Chander RJ, Lin X, Cordonnier C, Moulin S, Rossi C, Sabayan B, Stott DJ, Jukema JW, Melkas S, Jokinen H, Erkinjuntti T, Mok VCT, Wong A, Lam BYK, Leys D, Henon H, Bombois S, Sachdev P

Publication type: Article

Publication status: Published

Journal: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring

Year: 2017

Volume: 7

Pages: 11-23

Online publication date: 18/11/2016

Acceptance date: 02/04/2016

ISSN (print): 2352-8729

Publisher: Elsevier Inc

URL: https://doi.org/10.1016/j.dadm.2016.10.006

DOI: 10.1016/j.dadm.2016.10.006

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