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Change in diagnostic confidence brought about by using in utero MRI for fetal structural brain pathology: Analysis of the MERIDIAN cohort

Lookup NU author(s): Dr Paul Griffiths, Professor Steve RobsonORCiD


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© 2017.Aim: To measure possible change in diagnostic confidence by performing in utero magnetic resonance imaging (iuMRI) studies on fetuses with brain abnormalities recognised on ultrasonography (US). Materials and methods: The analyses are based on the primary cohort from the prospective MERIDIAN study, which consisted of 570 fetuses with brain abnormalities detected on US, with iuMRI performed within 2 weeks of US and complete outcome reference data. The cohort was recruited between July 2011 and August 2014, and written informed consent was obtained for all participants. They all had indicators of diagnostic confidence measured on US by fetal medicine experts and iuMRI by the reporting radiologists. Three assessments were carried out using the conventional uncorrected (C2-C1%) method, the conventional (C2-C1%) with the Omary correction, and the score-based weighted average method. Results: All three assessments showed statistically significant (p<0·0001) positive effects indicating that iuMRI was potentially beneficial when included in the diagnostic pathway for prenatal structural brain anomalies (in terms of diagnostic confidence). Conclusion: These results strongly support the routine clinical use of iuMRI as an adjunct to US when assessing fetuses with structural brain abnormalities.

Publication metadata

Author(s): Griffiths PD, Bradburn M, Campbell MJ, Connolly DJA, Cooper CL, Jarvis D, Kilby MD, Mason G, Mooney C, Robson SC, Wailoo A

Publication type: Article

Publication status: Published

Journal: Clinical Radiology

Year: 2017

Volume: 72

Issue: 6

Pages: 451-457

Print publication date: 01/06/2017

Online publication date: 24/02/2017

Acceptance date: 17/01/2017

ISSN (print): 0009-9260

ISSN (electronic): 1365-229X

Publisher: W.B. Saunders Ltd


DOI: 10.1016/j.crad.2017.01.009


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