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Modelling the molecular mechanisms of aging

Lookup NU author(s): Alvaro Martinez Guimera, David Hodgson, Neil McDonald, Dr Carole Proctor



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Author(s). The aging process is driven at the cellular level by random molecular damage that slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the aging process. The complexity of the aging process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards and discusses many specific examples of models that have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.

Publication metadata

Author(s): McAuley MT, Guimera AM, Hodgson D, McDonald N, Mooney KM, Morgan AE, Proctor CJ

Publication type: Review

Publication status: Published

Journal: Bioscience Reports

Year: 2017

Volume: 37

Issue: 1

Print publication date: 23/02/2017

Online publication date: 17/01/2017

Acceptance date: 16/01/2017

ISSN (print): 0144-8463

ISSN (electronic): 1573-4935

Publisher: Portland Press Ltd


DOI: 10.1042/BSR20160177

PubMed id: 28096317