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Lookup NU author(s): Professor Simon Thomas
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© 2017 Informa UK Limited, trading as Taylor & Francis Group Context: Grout, tile and floor stone sealants contain a solvent, a water-repelling agent and in the case of aerosols a propellant. The water-repelling agent used is typically a fluoropolymer resin, a silicon-based resin, or a combination of both. Objective: To report the clinical course in patients exposed to fluoropolymer-containing sealants referred to the United Kingdom National Poisons Information Service. Methods: A retrospective analysis was performed of telephone enquiries received between 2009 and 2015. Results: 101 enquiries involving 96 exposures were received. The majority of the exposures (n = 88) occurred when the sealant was delivered from an aerosol. Twelve patients were exposed occupationally and the remainder were exposed while using the product at home. Eighty-nine exposures were as a result of inhalation alone, two followed ingestion, three skin contact and one eye contact; one involved inhalation and eye contact. All 90 patients exposed by inhalation developed clinical features: 31 had a World Health Organisation/International Programme on Chemical Safety/European Commission/European Association of Poison Centres and Clinical Toxicologists Poisoning Severity Score of 1 (minor toxicity), 51 patients had features of moderate toxicity (PSS 2) and eight were graded PSS 3 (severe poisoning). The most common features were dyspnea (n = 52; 57.8%; 95% CI = 47.0–68.5), chest pain/tightness (n = 34; 37.8%; 95% CI = 27.2–48.4), coughing (n = 27; 30.0%; 95% CI = 20.0–40.0) and sinus tachycardia (n = 11; 12.2%; 95% CI = 4.1–18.2); hypoxemia was present in 20 (22.2%; 95% CI = 13.1–31.4). At the time of the enquiry a chest X-ray had been performed on 15 patients: in eight patients (all of whom were PSS 3) the X-ray was reported as being abnormal and showed bilateral shadowing. Conclusions: This study demonstrates that if fluoropolymer-containing sealants are inhaled then clinical features may occur and in a small proportion (9%) these features may be severe.
Author(s): Henke D, Campbell A, Bradberry SM, Sandilands EA, Thomas SHL, Thompson JP, Vale JA
Publication type: Article
Publication status: Published
Journal: Clinical Toxicology
Online publication date: 28/03/2017
Acceptance date: 11/01/2017
ISSN (print): 1556-3650
ISSN (electronic): 1556-9519
Publisher: Taylor and Francis Ltd
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