Toggle Main Menu Toggle Search

Open Access padlockePrints

Chronic rhinosinusitis and mood disturbance

Lookup NU author(s): Dr Sally Erskine, Emerita Professor Janet WilsonORCiD


Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


BACKGROUND: This study is part of the Chronic Rhinosinusitis Epidemiology Study (CRES). The overarching aim is to determine factors that influence the onset and severity of chronic rhinosinusitis (CRS). The aim of this analysis is to determine whether those with CRS are more likely to report psychiatric morbidity and in particular mood disturbance compared with healthy controls.METHODS: CRES consists of a study-specific questionnaire regarding demographic and socioeconomic factors and past medical history as well as a nasal symptom score (SNOT-22) and SF-36 (QoL - quality of life tool). Both of these tools contain mental health or emotional well-being domains. Participants were specifically asked whether they had ever consulted with their General Practitioner for anxiety or depression. Questionnaires were distributed to patients with CRS attending ENT outpatient clinics at 30 centres across the United Kingdom from 2007-2013. Controls were also recruited at these sites. Patients were divided into subgroups of CRS according to the absence/presence of polyps (CRSsNPs/CRSwNPs) or allergic fungal rhinosinusitis (AFRS).RESULTS: Consultations with a family physician for depression or anxiety were higher amongst those with CRS than controls, but this was only significant for those with CRSsNPs. Odds ratio (OR) for CRSsNPs vs controls: 1.89; OR for CRSwNPs: 1.40. Patients with CRS showed significantly higher mental health morbidity than controls across the mental health and emotional wellbeing domains of the SF-36 and SNOT-22. Mean difference in the mental health domain of SF-36 was 8.3 for CRSsNPs and 5.3 for CRSwNPs. For the emotional domain of SNOT-22, differences were 7.7 and 6.3 respectively.CONCLUSIONS: Depression and anxiety are significantly more common in patients with CRS compared to healthy controls, especially in those with CRSsNPs. This added mental health morbidity needs consideration when managing these patients in primary and secondary care settings

Publication metadata

Author(s): Erskine SE, Hopkins C, Clark A, Anari S, Robertson A, Sunkaraneni S, Wilson JA, Beezhold J, Philpott CM

Publication type: Article

Publication status: Published

Journal: Rhinology

Year: 2017

Volume: 55

Issue: 2

Pages: 113-119

Online publication date: 23/04/2017

Acceptance date: 01/08/2016

ISSN (print): 0300-0729

ISSN (electronic): 1996-8604

Publisher: International Rhinologic Society


DOI: 10.4193/Rhin16.111


Altmetrics provided by Altmetric