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Systems approaches in osteoarthritis: Identifying routes to novel diagnostic and therapeutic strategies

Lookup NU author(s): Dr Carole Proctor


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© 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. Systems orientated research offers the possibility of identifying novel therapeutic targets and relevant diagnostic markers for complex diseases such as osteoarthritis. This review demonstrates that the osteoarthritis research community has been slow to incorporate systems orientated approaches into research studies, although a number of key studies reveal novel insights into the regulatory mechanisms that contribute both to joint tissue homeostasis and its dysfunction. The review introduces both top-down and bottom-up approaches employed in the study of osteoarthritis. A holistic and multiscale approach, where clinical measurements may predict dysregulation and progression of joint degeneration, should be a key objective in future research. The review concludes with suggestions for further research and emerging trends not least of which is the coupled development of diagnostic tests and therapeutics as part of a concerted effort by the osteoarthritis research community to meet clinical needs.

Publication metadata

Author(s): Mueller AJ, Peffers MJ, Proctor CJ, Clegg PD

Publication type: Article

Publication status: Published

Journal: Journal of Orthopaedic Research

Year: 2017

Volume: 35

Issue: 8

Pages: 1573-1588

Print publication date: 01/08/2017

Online publication date: 20/03/2017

Acceptance date: 06/03/2017

ISSN (print): 0736-0266

ISSN (electronic): 1554-527X

Publisher: John Wiley and Sons Inc.


DOI: 10.1002/jor.23563


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