Browse by author
Lookup NU author(s): Dr Ilse Pienaar, Dr Joanna Elson
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
Abstract Mitochondrial DNA (mtDNA) association studies have been conducted for over a decade using the haplogroup (lineage) association method, but this frequently produces conflicting results. Here we analyzed complete mtDNA sequence data of Alzheimer’s disease (AD) patients and aged controls, from the United Kingdom (UK) and the United States (US), using a new "mutational load” method. We calculated a pathogenicity score for each of the non-synonymous substitutions of the mtDNA sequences to produce a “total mutational load” for each sequence, and compared the mutational loads of cases and controls. Using these mutational load measures, we found no evidence to support the cumulative role of mtDNA variants as a susceptibility factor in AD; that is, AD patients (UK and US cohorts) did not have higher “mutational loads” than controls. However, the US aged controls, who are significantly older than the UK ones, with many showing evidence of being healthy and having good cognition in old age, had significantly lower “mutational loads”. This finding suggests that low mtDNA mutational load is more prevalent in healthy older people.
Author(s): Pienaar IS, Howell N, Elson JL
Publication type: Article
Publication status: Published
Journal: Mitochondrion
Year: 2017
Volume: 34
Pages: 141-146
Print publication date: 01/05/2017
Online publication date: 07/04/2017
Acceptance date: 06/04/2017
Date deposited: 09/05/2017
ISSN (print): 1567-7249
ISSN (electronic): 1872-8278
Publisher: Elsevier
URL: http://doi.org/10.1016/j.mito.2017.04.002
DOI: 10.1016/j.mito.2017.04.002
Altmetrics provided by Altmetric
