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Physical activity and cardiovascular aging: Physiological and molecular insights

Lookup NU author(s): Professor Djordje JakovljevicORCiD



This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


© 2017 The Author. Aging is associated with significant changes in both cardiac and vascular structure and function that lower the threshold for clinical signs and symptoms, making older people more susceptible to cardiovascular diseases, morbidity and mortality. Understanding of age-related cardiovascular changes is necessary for effective and efficient prevention and treatment of cardiovascular disease in older people. Cardiac aging is associated with left ventricular remodelling marked by increased mass-to-volume ratio and accompanied by systolic and diastolic myocardial dysfunction, and reduced sensitivity to sympathetic stimuli that compromises myocardial contractility and pumping ability in older people. The vascular age-related remodelling is associated with increased arterial wall thickness, arterial stiffness, and an impaired endothelial vasoreactivity. Over the previous three decades of intensive research in cardiovascular aging, it became apparently clear that lifestyle factors such as physical activity and exercise play an important role in attenuating cardiovascular function decline with aging. This review highlights the effect of age on cardiac and vascular changes and their adaptations to exercise, providing physiological, molecular and cellular mechanisms that underlie diminished cardiovascular response in older age. It further describes cardiovascular differences between the individuals who maintain a physically active lifestyle, and who undergo exercise interventions in later life.

Publication metadata

Author(s): Jakovljevic DG

Publication type: Article

Publication status: Published

Journal: Experimental Gerontology

Year: 2018

Volume: 109

Pages: 67-74

Print publication date: 01/08/2018

Online publication date: 22/05/2017

Acceptance date: 21/05/2017

Date deposited: 19/06/2017

ISSN (print): 0531-5565

ISSN (electronic): 1873-6815

Publisher: Elsevier


DOI: 10.1016/j.exger.2017.05.016


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Funder referenceFunder name
MR/L016354/1Medical Research Council (MRC)