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Lookup NU author(s): Professor Anne Dickinson,
This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
© 2017 Dickinson, Norden, Li, Hromadnikova, Schmid, Schmetzer and Jochem-Kolb. The success of hematopoietic stem cell transplantation (HSCT) lies with the ability of the engrafting immune system to remove residual leukemia cells via a graft-versus-leukemia effect (GvL), caused either spontaneously post-HSCT or via donor lymphocyte infusion. GvL effects can also be initiated by allogenic mismatched natural killer cells, antigen-specific T cells, and activated dendritic cells of leukemic origin. The history and further application of this GvL effect and the main mechanisms will be discussed and reviewed in this chapter.
Author(s): Dickinson AM, Norden J, Li S, Hromadnikova I, Schmid C, Schmetzer H, Jochem-Kolb H
Publication type: Review
Publication status: Published
Journal: Frontiers in Immunology
Online publication date: 07/06/2017
Acceptance date: 10/04/2017
ISSN (print): 1664-3224
Publisher: Frontiers Research Foundation