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Lookup NU author(s): Dr Abigail Sharpe, Dr Peter Avery, Dr Meenakshi Choudhary
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© 2017 The British Fertility Society In 2013, the National Health Service Commissioning board centralized the funding in England for up to three cycles of pre-implantation genetic diagnosis (PGD) for couples who have, or are carriers of, a specific genetic disorder. This study presents the historical data of PGD cycles and their clinical outcomes in UK as extrapolated from the national data registry. Retrospective analysis of outcome of cycles undergoing pre-implantation genetic diagnosis in the UK over the past 20 years was performed from the Human Fertilisation and Embryology Authority database (n = 2974). Binary logistic regression was used to determine trends over time and adjusted for maternal age. Briefly, the number of PGD cycles has risen 127-fold from 1991 to 2012 with 3.6-fold increase (360% rise) from 2004 to 2012. A total of one in four embryos following pre-implantation genetic diagnosis did not reach embryo transfer and 92% of these were due to a failure to survive. The live birth rate has risen over 20 years and there has been a steady decline in reported incidence of congenital abnormalities (p < 0.07). PGD has thus emerged as a safe and effective alternative to prenatal diagnosis but with ever evolving technological advances, a robust system of data collection that incorporates techniques used and reporting of mutation-specific clinical outcomes is suggested.
Author(s): Sharpe A, Avery P, Choudhary M
Publication type: Article
Publication status: Published
Journal: Human Fertility
Year: 2018
Volume: 21
Issue: 2
Pages: 120-127
Online publication date: 12/06/2017
Acceptance date: 15/11/2016
ISSN (print): 1464-7273
ISSN (electronic): 1742-8149
Publisher: Taylor and Francis Ltd
URL: https://doi.org/10.1080/14647273.2017.1336259
DOI: 10.1080/14647273.2017.1336259
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