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Synthetic biodegradable medical polyurethanes

Lookup NU author(s): Dr Piergiorgio GentileORCiD


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© 2017 Elsevier Ltd All rights reserved. Polyurethanes (PURs) are a class of block copolymers synthesised from three different reagents: a polyol, a di- or multi-isocyanate, and a chain extender. Biodegradable PURs can be synthesised by properly selecting the building blocks with suitable properties for applications in regenerative medicine. The nature and relative amount of hard and soft segments affect the mechanical properties. PURs can be bulk or surface functionalised with biomimetic peptide sequences or natural polymers, affecting cell response and/or the biodegradation rate. PUR particles, fibres, and hydrogels can be designed with a suitable composition for drug encapsulation and controlled release. This chapter offers an overview of the chemistry of biodegradable and biocompatible PURs and reports their application as scaffolds for tissue engineering and carriers for drug delivery.

Publication metadata

Author(s): Chiono V, Sartori S, Calzone S, Boffito M, Tonda-Turo C, Mattu C, Gentile P, Ciardelli G

Editor(s): Xiang Zhang

Publication type: Book Chapter

Publication status: Published

Book Title: Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties

Year: 2017

Pages: 189-216

Online publication date: 30/09/2016

Acceptance date: 02/04/2016

Publisher: Woodhead Publishing

Place Published: Duxford


DOI: 10.1016/B978-0-08-100372-5.00006-4

Library holdings: Search Newcastle University Library for this item

ISBN: 9780081003930